Characterization A molecular features in iatroge

 
   Lead Investigator:    Ignazio Cali
   Institution      :    Case Western Reserve University
   E-Mail           :    ixc20@case.edu
   Proposal ID      :    937



   Proposal Description:
   I would like to request frozen brain tissue of the frontal, temporal, occipital  lobes, and cerebellum (~5 g for each region) from cases of late onset              Alzheimer's disease (LOAD) without Lewy Body (N=5), and cases with pre-clinical  Alzheimer's disease (N=5). LOAD should have cerebral amyloid angiopathy (CAA)      without cerebral ischemic infarction. For each of the 10 cases I would like to     know: 1)  neuropathological data, including the Braak stage, the presence of       neuritic plaques, and of neurofibrillary tangles 2) demographic data: age at       onset, disease duration, sex, and race and 3) APOE polymorphism (possibly no       APOE????4 alleles). Finally each case should not have a history of TBI.